Abstract
In contrast to peripheral lymphoid organs, in the liver a high proportion of T cells are CD4+NKT cells. We have previously reported that LFA-1 plays a pivotal role in the homing of thymic CD4+NKT cells to the liver. In the present study, we further assessed which cell type participates in the homing of thymic CD4+NKT cells to the liver. The accumulation of donor thymocyte-derived CD4+NKT cells in the liver of SCID mice that had been reconstituted with thymocytes from C57BL/6 mice was severely impaired by in vivo depletion of NK cells, but not Kupffer cells in recipients. These results suggest that NK cells participate in the homing of thymic CD4+NKT cells to the liver. We assume that LFA-1 expressed on NK cells is involved in this mechanism.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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CD4 Antigens / biosynthesis*
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Cell Movement / immunology*
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Female
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Killer Cells, Natural / cytology*
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Killer Cells, Natural / immunology
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Kupffer Cells / cytology
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Kupffer Cells / immunology
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Liver / cytology*
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Liver / immunology*
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Liver / metabolism
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Lymphocyte Function-Associated Antigen-1 / biosynthesis
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Lymphocyte Function-Associated Antigen-1 / genetics
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Lymphocyte Function-Associated Antigen-1 / physiology
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Lymphocyte Transfusion
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Mice
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Mice, Inbred C57BL
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Mice, Mutant Strains
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Mice, SCID
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T-Lymphocyte Subsets / cytology*
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T-Lymphocyte Subsets / immunology
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T-Lymphocyte Subsets / metabolism
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T-Lymphocyte Subsets / transplantation
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Thymus Gland / cytology*
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Thymus Gland / immunology
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Thymus Gland / metabolism
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Thymus Gland / transplantation
Substances
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CD4 Antigens
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Lymphocyte Function-Associated Antigen-1