Abstract
Orexin A and neuropeptide Y that are known to induce a feeding response when applied centrally, in the present studies also caused hypothermia. Neuropeptide Y elicited hypothermia by depressing metabolic rate (without affecting heat loss mechanisms), while orexin A acted through enhancing peripheral heat loss (without affecting metabolic rate). Neither peptide induced coordinated thermoregulatory changes, both of them appeared to influence thermoregulation via different effector mechanisms.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological
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Animals
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Appetite Stimulants / administration & dosage
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Appetite Stimulants / pharmacology*
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Body Temperature / drug effects
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Body Temperature Regulation / drug effects*
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Carrier Proteins / administration & dosage
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Carrier Proteins / pharmacology*
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Female
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Injections, Intraventricular
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Intracellular Signaling Peptides and Proteins*
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Neuropeptide Y / administration & dosage
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Neuropeptide Y / pharmacology*
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Neuropeptides / administration & dosage
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Neuropeptides / pharmacology*
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Orexins
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Rats
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Rats, Wistar
Substances
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Appetite Stimulants
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Carrier Proteins
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Intracellular Signaling Peptides and Proteins
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Neuropeptide Y
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Neuropeptides
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Orexins