Abstract
Human herpesvirus 6 (HHV-6) has been proposed as a potential cofactor in the progression of human immunodeficiency virus type 1 (HIV-1) disease. We used the SCID-hu Thy/Liv mouse model to evaluate the in vivo interactions between HHV-6 and HIV-1. Our results demonstrate that HHV-6 and HIV-1 can simultaneously replicate in the human thymus in vivo. In this model, however, the presence of one virus appears not to modify the replication or cytopathicity of the other.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cytopathogenic Effect, Viral
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DNA-Binding Proteins / analysis
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Flow Cytometry
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HIV Core Protein p24 / analysis
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HIV Infections / complications*
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HIV Infections / immunology
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HIV Infections / virology
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HIV-1 / immunology
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HIV-1 / physiology*
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Herpesviridae Infections / complications*
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Herpesviridae Infections / immunology
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Herpesviridae Infections / virology
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Herpesvirus 6, Human / immunology
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Herpesvirus 6, Human / physiology*
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Humans
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Immunohistochemistry
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Mice
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Mice, SCID
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T-Lymphocytes / virology
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Viral Proteins / analysis
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Virus Replication
Substances
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DNA-Binding Proteins
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HIV Core Protein p24
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Viral Proteins
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p41 protein, Human herpesvirus 6