De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability

MeSH terms

• Administration, Oral
• Adrenergic alpha-Antagonists / chemical synthesis*
• Adrenergic alpha-Antagonists / metabolism
• Adrenergic alpha-Antagonists / pharmacokinetics
• Adrenergic alpha-Antagonists / pharmacology
• Animals
• Aorta / drug effects
• Aorta / physiology
• Binding, Competitive
• Biological Availability
• Blood Pressure / drug effects
• Dogs
• Humans
• In Vitro Techniques
• Male
• Muscle Contraction / drug effects
• Muscle, Smooth / drug effects
• Muscle, Smooth / physiology
• Oxazoles / chemical synthesis*
• Oxazoles / metabolism
• Oxazoles / pharmacokinetics
• Oxazoles / pharmacology
• Pressure
• Prostate / drug effects
• Prostate / physiology
• Radioligand Assay
• Rats
• Receptors, Adrenergic, alpha-1 / drug effects*
• Recombinant Proteins / chemical synthesis
• Recombinant Proteins / metabolism
• Recombinant Proteins / pharmacokinetics
• Recombinant Proteins / pharmacology
• Urethra / drug effects
• Urethra / physiology