Nearly 15% of patients with systemic lupus erythematosus (SLE) present during adolescence; it is therefore highly likely that a pediatrician will care for a young adult with SLE in his or her practice. The author stresses the importance of an individualized medical treatment plan that suits the patient and disease stage, as well as the clinician's obligation to provide clear and accurate information to adolescents and their parents. Guidelines to facilitate patient compliance and understanding are also offered.