Abstract
This study was designed to determine whether CuZn-superoxide dismutase (SOD) is neuroprotective against aging in the nigrostriatal tract. Twenty-four male mice transgenic for human CuZnSOD, resulting in overexpression of the cytosolic enzyme, were compared with 11 matched controls over 19 months. There was no difference in longevity, locomotor activity, or 3H-mazindol or 3H-spiperone binding in the nigrostriatal tract in the two groups. Thus there was no evidence that increased CuZnSOD was neuroprotective in this model.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Binding Sites / drug effects
-
Binding Sites / genetics
-
Longevity / genetics*
-
Male
-
Mazindol / pharmacology*
-
Mice
-
Mice, Transgenic / metabolism
-
Motor Activity / genetics*
-
Neostriatum / enzymology*
-
Neostriatum / pathology
-
Neostriatum / physiopathology
-
Nerve Degeneration / enzymology
-
Nerve Degeneration / genetics
-
Nerve Degeneration / physiopathology
-
Neural Pathways / enzymology*
-
Neural Pathways / pathology
-
Neural Pathways / physiopathology
-
Neuroprotective Agents / metabolism
-
Oxidative Stress / genetics
-
Spiperone / pharmacology*
-
Substantia Nigra / enzymology*
-
Substantia Nigra / pathology
-
Substantia Nigra / physiopathology
-
Superoxide Dismutase / genetics
-
Superoxide Dismutase / metabolism*
-
Tritium
Substances
-
Neuroprotective Agents
-
Tritium
-
Spiperone
-
Mazindol
-
Superoxide Dismutase