Early vasculopathy following radiation in a child with medulloblastoma

Pediatr Neurosurg. 2000 May;32(5):255-8. doi: 10.1159/000028947.

Abstract

A child with severe radiation vasculopathy 15 months following radiation therapy for medulloblastoma is reported. The patient underwent surgical resection of a posterior fossa medulloblastoma, followed by chemotherapy and radiation therapy. He was treated with 55 Gy to the craniospinal axis. Fifteen months later, the patient presented with a subacute neurologic deterioration from multiple ischemic events that resulted from severe radiation vascular injury. We compare and contrast this case to similar case reports in the literature.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Ischemia / diagnostic imaging
  • Brain Ischemia / etiology
  • Cerebellar Neoplasms / drug therapy
  • Cerebellar Neoplasms / radiotherapy*
  • Cerebral Angiography
  • Cerebral Infarction / diagnostic imaging
  • Cerebral Infarction / etiology*
  • Cerebrovascular Circulation / radiation effects*
  • Child
  • Cranial Fossa, Posterior
  • Fatal Outcome
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Medulloblastoma / drug therapy
  • Medulloblastoma / radiotherapy*
  • Radiation Injuries / diagnostic imaging*
  • Radiation Injuries / etiology
  • Radiotherapy, Adjuvant / adverse effects*