Abstract
A dipole lattice model for lipid membranes and their interactions with peptides is presented. It uses the Langevin dipole method to calculate electrostatic interactions in the heterogeneous membrane environment. A series of test cases are presented, including spherical charges, dipoles, side chain analogs, and helical peptides. The model consistently produces qualitatively correct results.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alamethicin / chemistry
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Alamethicin / metabolism
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Membrane Lipids / chemistry
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Membrane Lipids / metabolism
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Membrane Proteins / chemistry*
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Membrane Proteins / metabolism
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Membranes / chemistry
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Models, Biological*
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Peptides / chemistry
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Peptides / metabolism
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Reproducibility of Results
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Static Electricity
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Thermodynamics
Substances
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Membrane Lipids
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Membrane Proteins
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Peptides
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Alamethicin