Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53

J Med Chem. 2000 Aug 24;43(17):3205-8. doi: 10.1021/jm990966p.

Authors

C García-Echeverría¹, P Chène, M J Blommers, P Furet

Affiliation

¹ Oncology Research and Core Technologies, Novartis Pharma Inc., CH-4002 Basel, Switzerland. [email protected]

PMID: 10966738
DOI: 10.1021/jm990966p

No abstract available

MeSH terms

Amino Acid Substitution
Crystallography, X-Ray
Humans
Ligands
Models, Molecular
Nuclear Proteins*
Peptide Fragments / chemistry
Peptides / chemical synthesis
Peptides / chemistry*
Proto-Oncogene Proteins / antagonists & inhibitors
Proto-Oncogene Proteins / chemistry*
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-mdm2
Structure-Activity Relationship
Tumor Suppressor Protein p53 / antagonists & inhibitors
Tumor Suppressor Protein p53 / chemistry*
Tumor Suppressor Protein p53 / metabolism

Substances

Ligands
Nuclear Proteins
Peptide Fragments
Peptides
Proto-Oncogene Proteins
Tumor Suppressor Protein p53
MDM2 protein, human
Proto-Oncogene Proteins c-mdm2