Abstract
CD8 T cells exist in a dynamic network whose repertoire remains static in the absence of infection but changes in the presence of foreign antigens. Individuals each have unique T-cell repertoires that continually evolve in the presence of antigen and of cross-reactive heterologous antigens, and homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory cells into a finite immune system.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens, Viral
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CD8-Positive T-Lymphocytes / immunology*
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Epstein-Barr Virus Infections / immunology*
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Epstein-Barr Virus Infections / virology
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Flow Cytometry
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Herpesvirus 4, Human / immunology
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Interferon-gamma / analysis
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Lymphocytic Choriomeningitis / immunology*
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Lymphocytic Choriomeningitis / virology
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Lymphocytic choriomeningitis virus / immunology
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Spleen / immunology
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T-Lymphocyte Subsets / immunology
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Virus Latency
Substances
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Antigens, Viral
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Receptors, Antigen, T-Cell, alpha-beta
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Interferon-gamma