Radiolabeling of paclitaxel with electrophilic 123I

Bioorg Med Chem. 2000 Jan;8(1):65-8. doi: 10.1016/s0968-0896(99)00255-2.

Abstract

123I-Labeled paclitaxel, [123I]-1 was prepared by electrophilic aromatic radioiodination of 3'-N-(p-trimethylstannylbenzoyl)-3'-debenzoylpaclitaxel 2 with 123I- in the presence of peracetic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Iodine Radioisotopes / chemistry*
  • Paclitaxel / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Iodine Radioisotopes
  • Paclitaxel