Abstract
Investigation of extracts of Fissistigma balansae and Fissistigma oldhamii resulted in the isolation of 11 aristolactams-stigmalactam (1), piperolactam A (2), piperolactam C (3), aristolactam AII (4), aristolactam AIIIa (5), aristolactam BII (6), aristolactam BIII (7), aristolactam FII (8), goniothalactam (9), enterocarpam I (10), and velutinam (11)-as well as two dioxoaporphines, noraristolodione (12) and norcepharadione B (13). The new compound 1 was identified by spectral data interpretation. Compounds 1-13 were subjected to antiplatelet aggregation testing.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Assay
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Blood Platelets / drug effects
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Cell Aggregation / drug effects
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China
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Chromatography, Gel
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Chromatography, Thin Layer
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Gas Chromatography-Mass Spectrometry
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Lactams / chemistry
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Lactams / isolation & purification*
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Lactams / pharmacology
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Magnetic Resonance Spectroscopy
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification
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Phenanthrenes / pharmacology
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Plant Stems / chemistry*
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Plants / chemistry
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Rabbits
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Taiwan
Substances
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Lactams
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Phenanthrenes
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stigmalactam