New substituted 2-(pyrazol-1-yl) o-, m-, p-methylacetanilides with potential local anaesthetic and antiarrhythmic action. Part I

M Iovu; C Zalaru; F Dumitrascu; C Draghici; E Cristea

doi:10.1016/s0014-827x(00)00052-5

New substituted 2-(pyrazol-1-yl) o-, m-, p-methylacetanilides with potential local anaesthetic and antiarrhythmic action. Part I

Farmaco. 2000 May;55(5):362-8. doi: 10.1016/s0014-827x(00)00052-5.

Authors

M Iovu¹, C Zalaru, F Dumitrascu, C Draghici, E Cristea

Affiliation

¹ University of Medicine and Pharmaceutics Carol Davila, Department of Organic Chemistry, Bucharest, Romania. [email protected]

PMID: 10983281
DOI: 10.1016/s0014-827x(00)00052-5

Abstract

Fifteen substituted 2-(pyrazol-1-yl)acetanilides were synthesized by N-alkylation of pyrazole and some of its derivatives with several 2-iodoacetanilides. The new compounds exhibited local anaesthetic and antiarrhythmic actions. The new compounds have been characterized by elemental chemical analysis, UV-Vis, IR, 1H, 13C NMR spectra and pharmacology research.

MeSH terms

Acetanilides / chemistry
Acetanilides / pharmacology*
Anesthetics, Local / chemistry
Anesthetics, Local / pharmacology*
Animals
Anti-Arrhythmia Agents / chemistry
Anti-Arrhythmia Agents / pharmacology*
Lethal Dose 50
Mice
Spectrum Analysis

Substances

Acetanilides
Anesthetics, Local
Anti-Arrhythmia Agents