Nonparametric estimation for the three-stage irreversible illness-death model

Biometrics. 2000 Sep;56(3):841-7. doi: 10.1111/j.0006-341x.2000.00841.x.

Abstract

In this paper, we present new nonparametric estimators of the stage-occupation probabilities in the three-stage irreversible illness-death model. These estimators use a fractional risk set and a reweighting approach and are valid under stage-dependent censoring. Using a simulated data set, we compare the behavior of our estimators with previously proposed estimators. We also apply our estimators to data on time to Pneumocystis pneumonia and death obtained from an AIDS cohort study.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS-Related Opportunistic Infections / mortality
  • AIDS-Related Opportunistic Infections / physiopathology
  • Biometry / methods
  • Humans
  • Models, Biological*
  • Models, Statistical*
  • Pneumonia, Pneumocystis / mortality
  • Pneumonia, Pneumocystis / physiopathology
  • Risk Factors
  • Statistics, Nonparametric*
  • Survival Rate