Abstract
Objective:
To investigate the presence of angiogenic factors in benign, premalignant and malignant vulvar lesions.
Study design:
Immunohistochemical demonstration of vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) in normal vulvar skin, lichen sclerosus, vulvar intraepithelial neoplasia (VIN) and vulvar cancer.
Results:
VEGF was found in the majority of vulvar cancers but only a minority of VIN lesions. PD-ECGF was found in the majority of lesions.
Conclusion:
Demonstration of angiogenesis may suggest which preinvasive lesions will progress to invasive cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carcinoma in Situ / metabolism
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Carcinoma in Situ / pathology*
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Endothelial Growth Factors / metabolism
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Female
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Humans
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Immunohistochemistry
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Lichen Sclerosus et Atrophicus / metabolism
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Lichen Sclerosus et Atrophicus / pathology*
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Lymphokines / metabolism
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Neovascularization, Pathologic*
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Precancerous Conditions / metabolism
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Precancerous Conditions / pathology*
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Thymidine Phosphorylase / metabolism
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
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Vulvar Diseases / metabolism
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Vulvar Diseases / pathology*
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Vulvar Neoplasms / metabolism
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Vulvar Neoplasms / pathology*
Substances
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Endothelial Growth Factors
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Lymphokines
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Vascular Endothelial Growth Factor A
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Vascular Endothelial Growth Factors
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Thymidine Phosphorylase