Microbiology. How to get along--friendly microbes in a hostile world

R J Xavier; D K Podolsky

doi:10.1126/science.289.5484.1483

Microbiology. How to get along--friendly microbes in a hostile world

Science. 2000 Sep 1;289(5484):1483-4. doi: 10.1126/science.289.5484.1483.

Authors

R J Xavier¹, D K Podolsky

Affiliation

¹ Gastrointestinal Unit, Massachusetts General Hospital, 55 Fruit Street, GRJ-719, Boston, MA 02114, USA.

PMID: 10991734
DOI: 10.1126/science.289.5484.1483

Abstract

Microbiologists have long been puzzled by the finding that the gut mucosa does not respond to the myriad varieties of bacteria that normally reside in the gut. As Xavier and Podolsky explain in their Perspective, this may be because bacteria that are indigenous to the gut have learned ways to switch off pathways in gut epithelial cells that lead to switching on of genes involved in inflammation (Neish et al.).

Publication types

Comment

MeSH terms

Cell Nucleus / metabolism
Colon
Cytokines / genetics
Cytoplasm / metabolism
Gene Expression Regulation
Humans
I-kappa B Proteins / metabolism*
Inflammation
Intestinal Mucosa / metabolism*
Intestinal Mucosa / microbiology*
NF-kappa B / metabolism*
Salmonella / pathogenicity
Salmonella / physiology*
Tumor Cells, Cultured
Ubiquitins / metabolism

Substances

Cytokines
I-kappa B Proteins
NF-kappa B
Ubiquitins