Short high-voltage pulses have been shown to increase, accelerate and broaden transdermal drug delivery to molecules of variable physicochemical properties, i.e., from 18 to 38,000 Da, hydro- and lipophilic, neutral and charged molecules, via a mechanism hypothesized to involve electroporation of the stratum corneum lipid bilayers. Transport is increased by up to 4 orders of magnitude, and onset times for significant transport reduce from hours by passive diffusion to a few minutes.