CD8+ T cell populations in common variable immunodeficiency

Immunobiology. 2000 Aug;202(2):168-71. doi: 10.1016/S0171-2985(00)80062-5.

Abstract

In a subgroup of CVID T cell abnormalities have been reported. Peripheral blood T lymphocytes from patients with common variable immunodeficiency (CVID) and blood donors were examined for expression of CD8alpha, CD8beta and CD28. In CVID, three CD8+ T cells could be defined: CD8beta(high)CD28+ (expressing CD8beta at a high median fluorescence intensity), CD8beta(low)CD28+ and CD8beta(low) CD28- cells. The number of CD8beta(low) cells was markedly increased compared to blood donors. After activation, CD8beta(high)CD28+ cells from cord blood differentiated into CD8beta(low) CD28- cells. Therefore, CD8beta(low) cells are induced by activation even in normal donors, but may reflect inflammatory activity in CVID.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD8-Positive T-Lymphocytes / classification*
  • CD8-Positive T-Lymphocytes / cytology
  • Common Variable Immunodeficiency / blood
  • Common Variable Immunodeficiency / immunology*
  • Flow Cytometry / methods
  • Humans