Antisense therapy in cancer

Cancer Treat Rev. 2000 Oct;26(5):333-50. doi: 10.1053/ctrv.2000.0173.

Abstract

This review discusses laboratory and clinical studies of antisense oligodeoxynucleotides as potential treatments for haematological malignancies and solid tumours. Mechanisms of action, pharmacokinetics, toxicities and potential clinical applications of these agents are described.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Biological Transport
  • Drug Resistance, Multiple
  • Humans
  • Neoplasms / drug therapy*
  • Oligonucleotides, Antisense / adverse effects
  • Oligonucleotides, Antisense / pharmacokinetics
  • Oligonucleotides, Antisense / therapeutic use*
  • Oncogenes / genetics

Substances

  • Oligonucleotides, Antisense