Abstract
With use of a randomized, placebo-controlled trial, 62 healthy, postmenopausal smokers and nonsmokers were tested for resting and stress-induced hemodynamic variables before and after 6 months of treatment with either oral hormone replacement therapy or placebo. Smokers had significantly less reduction in both resting and stress-induced vascular resistance and blood pressure after treatment with oral hormone replacement therapy than nonsmokers.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Blood Pressure / drug effects
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Double-Blind Method
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Estrogens, Conjugated (USP) / pharmacology*
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Female
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Hemodynamics / drug effects*
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Hormone Replacement Therapy*
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Humans
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Medroxyprogesterone / pharmacology
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Postmenopause / physiology*
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Smoking / physiopathology*
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Vascular Resistance / drug effects
Substances
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Estrogens, Conjugated (USP)
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Medroxyprogesterone