Chiral discrimination in hydrogen-bonded

Org Lett. 2000 Oct 5;2(20):3169-72. doi: 10.1021/ol006366y.

Abstract

A series of racemic [7]helicenes have been prepared and characterized both in solution and in the solid state. Despite the helicenes having the ability to self-assemble in a variety of stereochemical and topological relationships, they formed only enantiomerically pure dimers held together by two pairs of cooperative hydrogen bonds. The self-assembly process was enantiospecific in solution and diastereoselective in the crystal.