Abstract
Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial deprivation of cerebral cholinergic functions caused by intracerebroventricular injections of AF64A. The effects of dimebon on learning are similar to those of tacrine used in the treatment of Alzheimer's disease.
MeSH terms
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Alzheimer Disease / chemically induced
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Alzheimer Disease / drug therapy*
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Alzheimer Disease / psychology
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Animals
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Avoidance Learning / drug effects
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Aziridines / pharmacology
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Choline / analogs & derivatives*
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Choline / pharmacology
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Cholinesterase Inhibitors / pharmacology
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Disease Models, Animal*
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Histamine H1 Antagonists / pharmacology*
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Indoles / pharmacology*
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Injections, Intraventricular
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Male
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Neuromuscular Blocking Agents / pharmacology
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Rats
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Rats, Wistar
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Tacrine / pharmacology
Substances
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Aziridines
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Cholinesterase Inhibitors
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Histamine H1 Antagonists
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Indoles
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Neuromuscular Blocking Agents
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Tacrine
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ethylcholine aziridinium
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Choline
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latrepirdine