HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein

A H Brandenburg; L de Waal; H H Timmerman; P Hoogerhout; R L de Swart; A D Osterhaus

doi:10.1128/jvi.74.21.10240-10244.2000

HLA class I-restricted cytotoxic T-cell epitopes of the respiratory syncytial virus fusion protein

J Virol. 2000 Nov;74(21):10240-4. doi: 10.1128/jvi.74.21.10240-10244.2000.

Authors

A H Brandenburg¹, L de Waal, H H Timmerman, P Hoogerhout, R L de Swart, A D Osterhaus

Affiliation

¹ Institute of Virology, Erasmus University Hospital, 3000 DR Rotterdam, The Netherlands.

Abstract

Virus-specific cytotoxic T lymphocytes (CTL) play a major role in the clearance of respiratory syncytial virus (RSV) infection. We have generated cytotoxic T-cell clones (TCC) from two infants who had just recovered from severe RSV infection. These TCC were functionally characterized and used to identify HLA class I (B57 and C12)-restricted CTL epitopes of RSV.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Epitope Mapping
Epitopes, T-Lymphocyte / immunology*
Histocompatibility Antigens Class I / immunology*
Histocompatibility Antigens Class I / metabolism
Humans
Infant
Infant, Newborn
Respiratory Syncytial Virus Infections / virology
Respiratory Syncytial Viruses / immunology*
T-Lymphocytes, Cytotoxic / immunology*
Viral Fusion Proteins / immunology*
Viral Proteins / immunology*

Substances

Epitopes, T-Lymphocyte
Histocompatibility Antigens Class I
Viral Fusion Proteins
Viral Proteins