Abstract
Objective:
To observe the expression of MAL gene mRNA in esophageal cancer tissue and adjacent epithelial mucosa.
Methods:
Non-radioactive RNA in situ hybridization.
Results:
MAL gene was expressed in all epithelia of 33 matched samples but only in 8 of esophageal cancer tissues. Differential expression between esophageal cancer tissues and adjacent epithelia was not related to clinical parameters.
Conclusion:
Down-regulation of MAL may be an important event in the development of esophageal cancer.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
MeSH terms
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Down-Regulation
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Esophageal Neoplasms / genetics*
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Gene Expression Regulation, Neoplastic
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Humans
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In Situ Hybridization*
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Membrane Transport Proteins*
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Myelin Proteins*
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Myelin and Lymphocyte-Associated Proteolipid Proteins
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Proteolipids / genetics*
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RNA, Messenger / analysis
Substances
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MAL protein, human
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Membrane Transport Proteins
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Myelin Proteins
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Myelin and Lymphocyte-Associated Proteolipid Proteins
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Proteolipids
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RNA, Messenger