Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace

M Adamska; S Léger; M Brand; T Hadrys; T Braun; E Bober

doi:10.1016/s0925-4773(00)00414-7

Inner ear and lateral line expression of a zebrafish Nkx5-1 gene and its downregulation in the ears of FGF8 mutant, ace

Mech Dev. 2000 Oct;97(1-2):161-5. doi: 10.1016/s0925-4773(00)00414-7.

Authors

M Adamska¹, S Léger, M Brand, T Hadrys, T Braun, E Bober

Affiliation

¹ Department of Molecular and Cellular Biology, Technical University, Braunschweig, Spielmannstrasse 7, D-38106, Braunschweig, Germany.

PMID: 11025218
DOI: 10.1016/s0925-4773(00)00414-7

Abstract

An orthologue of the mouse homeobox gene Nkx5-1 was cloned and characterized in the zebrafish. As in the mouse and chick, the zebrafish Nkx5-1 gene is expressed in the ear placode and vesicle and in cells forming the vestibulo-acoustic ganglion. In addition, a novel expression domain, the lateral line, appears in the zebrafish, supporting a common precursor hypothesis for these two organs. In the FGF8 zebrafish mutant ace, expression of Nkx5-1 in the otic structures is diminished. The most significant reduction of zfNkx5-1 expression was observed in cells of the vestibulo-acoustic ganglion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Animals
Brain / embryology
Brain / metabolism
DNA, Complementary
Down-Regulation*
Ear, Inner / embryology
Ear, Inner / metabolism*
Fibroblast Growth Factor 8
Fibroblast Growth Factors / genetics*
Gene Expression Regulation, Developmental*
Homeodomain Proteins / genetics*
Humans
Mechanoreceptors / embryology
Mechanoreceptors / metabolism
Mice
Molecular Sequence Data
Nerve Tissue Proteins / genetics*
Rats
Sequence Homology, Amino Acid
Signal Transduction
Zebrafish

Substances

DNA, Complementary
Hmx3 protein, mouse
Homeodomain Proteins
Nerve Tissue Proteins
Fibroblast Growth Factor 8
Fibroblast Growth Factors