Altered gene expression upon BCR cross-linking in Burkitt's lymphoma B cell line

Biochem Biophys Res Commun. 2000 Oct 14;277(1):124-7. doi: 10.1006/bbrc.2000.3639.

Abstract

Burkitt's lymphoma cell line, BL2 was stimulated by surface BCR cross-linking and altered gene expression was analyzed by RDA methodology. Consistent with previous reports, we detected up-regulated MDC, IL6R and adhesion molecule LFA1. We also detected gene expression of SIRPalpha, anti-apoptotic A-20, signal regulatory SLP76 and BCAR3, DNA binding proteins EGR2 and DEC1 in addition to some new genes.

MeSH terms

  • Antibodies / immunology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism*
  • Burkitt Lymphoma / genetics*
  • Burkitt Lymphoma / pathology
  • Cell Differentiation
  • Cloning, Molecular
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Immunoglobulin M / immunology*
  • Immunoglobulin M / metabolism
  • Lymphocyte Activation / genetics*
  • Lymphocyte Activation / immunology
  • Molecular Sequence Data
  • Neoplasm Proteins / genetics
  • Polymerase Chain Reaction
  • RNA, Messenger / analysis
  • RNA, Messenger / genetics
  • Receptor Aggregation*
  • Signal Transduction
  • Tumor Cells, Cultured

Substances

  • Antibodies
  • Immunoglobulin M
  • Neoplasm Proteins
  • RNA, Messenger

Associated data

  • GENBANK/AI433612
  • GENBANK/AI567785
  • GENBANK/AW755261