Stereoselective synthesis of the alpha-glycoside of a KDO "C"-disaccharide

Org Lett. 2000 Oct 19;2(21):3361-3. doi: 10.1021/ol006458n.

Abstract

The reaction of tert-butyl (4,5,7, 8-tetra-O-acetyl-3-deoxy-alpha-D-manno-2-octulopyranosyl chloride)onate donor 7 with the 6-formylgalactopyranoside acceptor 4 in the presence of SmI(2) provided only the KDO alpha-C-disaccharide 8. The bulky tert-butyl ester in the donor was used to reverse the stereochemical outcome of C-glycosylation, stereoselectively forming the alpha-"C"-disaccharide of KDO.

MeSH terms

  • Carbohydrate Sequence
  • Disaccharides / chemistry*
  • Glycosides / chemical synthesis*
  • Glycosides / chemistry
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Disaccharides
  • Glycosides