Abstract
We cloned the cDNAs encoding the feline homologues of B-lymphocyte activation antigens B7-1 (CD80) and B7-2 (CD86). We expressed recombinant feline CD80 and CD86 molecules by the baculovirus expression system, and demonstrated their binding ability to human CTLA4-murine immunoglobulin fusion protein.
MeSH terms
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Abatacept
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Amino Acid Sequence
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Animals
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Antigens, CD / genetics*
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Antigens, Differentiation / genetics*
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B-Lymphocytes*
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B7-1 Antigen / genetics*
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B7-2 Antigen
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CTLA-4 Antigen
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Cats
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Cloning, Molecular
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DNA, Complementary / genetics*
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DNA, Complementary / isolation & purification
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Humans
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Immunoconjugates*
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Lymphocyte Activation / genetics
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Membrane Glycoproteins / genetics*
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Mice
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Molecular Sequence Data
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Sequence Alignment
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Sequence Homology, Amino Acid
Substances
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Antigens, CD
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Antigens, Differentiation
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B7-1 Antigen
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B7-2 Antigen
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CD86 protein, human
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CTLA-4 Antigen
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CTLA4 protein, human
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Cd86 protein, mouse
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Ctla4 protein, mouse
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DNA, Complementary
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Immunoconjugates
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Membrane Glycoproteins
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Abatacept
Associated data
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GENBANK/AB030651
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GENBANK/AB030652