Abstract
Drug interactions may lead to adverse drug effects or therapeutic failure. Many clinically relevant unwanted interactions are caused by a change in the activity of cytochrome P450 isoenzymes or the activity of active drug transport systems (e.g. p-glycoprotein). Most drug interactions may be anticipated and prevented by dose modification or using alternative drugs.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B / metabolism
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Cytochrome P-450 Enzyme System / metabolism*
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Drug Interactions*
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Drug-Related Side Effects and Adverse Reactions*
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Humans
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Pharmaceutical Preparations / metabolism
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Pharmacokinetics
Substances
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ATP Binding Cassette Transporter, Subfamily B
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Pharmaceutical Preparations
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Cytochrome P-450 Enzyme System