Abstract
Avascular necrosis (AVN) of head of the femur is associated with various pathological conditions and treatment modalities. We present a case of acute promyelocytic leukemia who was treated with all-transretinoic acid (ATRA), daunomycin, cytarabine and a short course of dexamethasone. He developed AVN of bone after 2 years of treatment. Whether this is related to ATRA is dealt with in the discussion.
MeSH terms
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Adult
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Cytarabine / administration & dosage
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Daunorubicin / administration & dosage
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Dexamethasone / administration & dosage
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Femur Head Necrosis / chemically induced
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Femur Head Necrosis / etiology*
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Humans
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Leukemia, Promyelocytic, Acute / complications*
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Leukemia, Promyelocytic, Acute / drug therapy
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Male
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Tretinoin / administration & dosage
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Tretinoin / adverse effects*
Substances
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Cytarabine
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Tretinoin
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Dexamethasone
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Daunorubicin