Abstract
A major consequence of diabetes mellitus type 2 is the accelerated development of atherosclerosis. Assessment of conventional risk factors such as plasma lipids, lipoproteins and hypertension only partly account for the excessive risk of developing cardiovascular disease in this population. Increasing evidence has emerged suggesting that conditions associated with diabetes mellitus type 2, such as insulin resistance, hyperinsulinemia and hyperglycemia, may also play a significant role in regulating 'novel' cardiovascular risk factors. These factors and their potential roles in the development of atherosclerosis and cardiovascular events are discussed in this review.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Arteriosclerosis / etiology
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Arteriosclerosis / metabolism
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Blood Glucose / metabolism
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Cardiovascular Diseases / etiology*
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Cardiovascular Diseases / metabolism
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Diabetes Mellitus, Type 2 / complications*
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Diabetes Mellitus, Type 2 / metabolism
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Diabetic Angiopathies / etiology
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Diabetic Angiopathies / metabolism
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Endothelium, Vascular / physiopathology
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Glycation End Products, Advanced / metabolism
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Humans
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Hyperlipidemias / complications
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Inflammation Mediators / blood
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Lipoproteins, LDL / metabolism
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Models, Biological
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Monocytes / physiology
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Oxidative Stress
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Risk Factors
Substances
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Blood Glucose
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Glycation End Products, Advanced
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Inflammation Mediators
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Lipoproteins, LDL
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oxidized low density lipoprotein