Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives

N Bharti; M R Maurya; F Naqvi; A Azam

doi:10.1016/s0960-894x(00)00446-7

Synthesis and antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 2-acetylpyridine and benzimidazole derivatives

Bioorg Med Chem Lett. 2000 Oct 16;10(20):2243-5. doi: 10.1016/s0960-894x(00)00446-7.

Authors

N Bharti¹, M R Maurya, F Naqvi, A Azam

Affiliation

¹ Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.

PMID: 11055329
DOI: 10.1016/s0960-894x(00)00446-7

Abstract

Reaction of [Ru(eta4-C8H12) (CH3CN)2 Cl2] with 2-(2-pyridyl) benzimidazole or Schiff bases derived from 2-acetylpyridine and S-methyldithiocarbazate, S-benzyldithiocarbazate and thiosemicarbazide leads to form new complexes of the type [Ru(eta4-C8H12)(L)Cl2] (where L=ligand). In vitro, most of the compounds exhibited potent activity and the Ru derivatives 1a [Ru(eta4-C8H12)(2-Acpy-SMDT)Cl2], 2a [Ru(eta4-C8H12)(2-Acpy-SBDT)Cl2] and 3a [Ru(eta4-CsH12)(2-Acpy-TSC)Cl2] were found more active than metronidazole against (HK-9) strain of Entamoeba histolytica.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amebicides / chemical synthesis*
Amebicides / chemistry
Amebicides / toxicity
Animals
Benzimidazoles / chemical synthesis*
Benzimidazoles / chemistry
Benzimidazoles / toxicity
Entamoeba histolytica / drug effects
Indicators and Reagents
Organometallic Compounds / chemical synthesis*
Organometallic Compounds / chemistry
Organometallic Compounds / toxicity
Pyridines
Rhodium*
Schiff Bases
Structure-Activity Relationship

Substances

Amebicides
Benzimidazoles
Indicators and Reagents
Organometallic Compounds
Pyridines
Schiff Bases
Rhodium