Abstract
Two new 3,6-epidioxy-7,10-tetrahydrofurano C(26) unsaturated fatty acids, stolonic acids A (1) and B (2), were isolated from a previously undescribed ascidian species, Stolonica sp. collected off the Maldive Islands in the Indian Ocean. The structures and relative stereochemistry of 1 and 2 were determined using conventional spectroscopic methods. Both compounds exhibited antiproliferative activity against selected human melanoma and ovarian tumor cell lines, with IC(50) values of approximately 0.05-0.1 microg/mL.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Drug Screening Assays, Antitumor
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification*
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Fatty Acids, Unsaturated / pharmacology
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Furans / chemistry
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Furans / isolation & purification*
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Furans / pharmacology
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Humans
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Indian Ocean
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Peroxides / chemistry
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Peroxides / isolation & purification*
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Peroxides / pharmacology
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Tumor Cells, Cultured
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Urochordata / chemistry*
Substances
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Antineoplastic Agents
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Fatty Acids, Unsaturated
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Furans
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Peroxides
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stolonic acid A
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stolonic acid B