Abstract
A decamer of a beta-amino acid analogue of L-proline, (3R)-carboxy pyrrolidine (beta-proline), was synthesized from a readily available (R)-glycidol. It was found to possess a rigid secondary structure, as evidenced by its CD spectrum. The beta-proline decamer, however, failed to bind to profilin, whereas the corresponding alpha-L-proline decamer bound tightly to this protein.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Circular Dichroism
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Contractile Proteins*
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Microfilament Proteins / metabolism*
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Molecular Structure
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / metabolism
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Profilins
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Protein Conformation
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Protein Structure, Secondary
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Pyrrolidines / chemical synthesis*
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Spectrometry, Fluorescence
Substances
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Contractile Proteins
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Microfilament Proteins
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Oligopeptides
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Profilins
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Pyrrolidines