Major complications during spasm provocation tests with an intracoronary injection of acetylcholine

Am J Cardiol. 2000 Feb 1;85(3):391-4, A10. doi: 10.1016/s0002-9149(99)00754-7.

Abstract

This study sought to clarify major complications associated with acetylcholine testing. Serious major complications, such as sustained ventricular tachycardia, shock, and cardiac tamponade were determined in 4 of 715 patients (0.56%), but no cases of death or irreversible complications occurred. The spasm provocation test using acetylcholine should be performed carefully, although it is considered a safe and reliable method.

MeSH terms

  • Acetylcholine / administration & dosage
  • Acetylcholine / adverse effects*
  • Aged
  • Coronary Angiography
  • Coronary Disease / diagnosis
  • Coronary Disease / diagnostic imaging
  • Coronary Vasospasm / chemically induced*
  • Coronary Vasospasm / diagnostic imaging
  • Female
  • Humans
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / adverse effects*

Substances

  • Vasodilator Agents
  • Acetylcholine