Abstract
A cell culture system and double fluorogenic staining were used to study the susceptibility of Cryptosporidium parvum to membrane-active antibiotics. Buforin II and magainin II exerted a cytotoxic effect on sporozoites but did not consistently affect oocyst viability. Lasalocid and nigericin demonstrated less activity against sporozoites but reduced the infectivity of oocysts.
MeSH terms
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Animals
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Anti-Infective Agents / pharmacology*
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Antimicrobial Cationic Peptides / pharmacology*
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Cell Membrane / drug effects
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Cryptosporidium parvum / cytology
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Cryptosporidium parvum / drug effects*
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Drug Evaluation, Preclinical
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Flow Cytometry
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Fluorescent Dyes
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Humans
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Magainins
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Proteins / pharmacology*
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Time Factors
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Tumor Cells, Cultured / drug effects
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Tumor Cells, Cultured / parasitology
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Xenopus Proteins*
Substances
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Anti-Infective Agents
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Antimicrobial Cationic Peptides
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Fluorescent Dyes
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Magainins
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Proteins
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Xenopus Proteins
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buforin II
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magainin 2 peptide, Xenopus