Acute myeloid leukemia with hypergranular cytoplasm: a differential diagnosis of acute promyelocytic leukemia

Leuk Res. 2000 Nov;24(11):979-82. doi: 10.1016/s0145-2126(00)00068-0.

Abstract

We report here the case of a woman with acute myeloid leukemia with some blast cells exhibiting acute promyelocytic leukemia (APL)-like hypergranular cytoplasm. The cytologic and cytochemical aspects as well as the mature myeloid phenotype and hemostasis disorders were consistent with the diagnosis of APL. However, no t(15;17), or RARalpha gene, MLL gene or PML gene rearrangement was observed, or any other cytogenetic clonal abnormality. Coexpression on blast cells of CD33 and CD56 without CD34, CD16 or HLA-DR, suggested a myeloid/natural killer cell acute leukemia.

Publication types

  • Case Reports

MeSH terms

  • Blast Crisis / pathology*
  • Bone Marrow Cells / pathology*
  • Cytoplasm / pathology
  • Cytoplasmic Granules / pathology*
  • DNA-Binding Proteins / genetics
  • Diagnosis, Differential
  • Female
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Leukemia, Promyelocytic, Acute / diagnosis*
  • Leukemia, Promyelocytic, Acute / genetics
  • Leukemia, Promyelocytic, Acute / pathology
  • Middle Aged
  • Myeloid-Lymphoid Leukemia Protein
  • Neoplasm Proteins / genetics
  • Nuclear Proteins*
  • Peroxidase / analysis
  • Promyelocytic Leukemia Protein
  • Proto-Oncogenes*
  • Receptors, Retinoic Acid / genetics
  • Retinoic Acid Receptor alpha
  • Transcription Factors / genetics
  • Tumor Suppressor Proteins
  • Zinc Fingers

Substances

  • DNA-Binding Proteins
  • KMT2A protein, human
  • Neoplasm Proteins
  • Nuclear Proteins
  • Promyelocytic Leukemia Protein
  • RARA protein, human
  • Receptors, Retinoic Acid
  • Retinoic Acid Receptor alpha
  • Transcription Factors
  • Tumor Suppressor Proteins
  • PML protein, human
  • Myeloid-Lymphoid Leukemia Protein
  • Peroxidase
  • Histone-Lysine N-Methyltransferase