Abstract
A highly potent anti-MRSA sesquiterpenoid has been isolated from Ulmus davidiana var. japonica, which has been traditionally used to treat infectious diseases in Korea. This naturally occurring antibiotic was identified as mansonone F (1). This compound has been found to be highly active specifically against MRSA and showed an MIC range of 0.39-3.13 microg/ml which is comparable to that of vancomycin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects
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Korea
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Methicillin Resistance*
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Microbial Sensitivity Tests
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Plant Epidermis / chemistry
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Quinones / isolation & purification
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Quinones / pharmacology*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology*
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Staphylococcus aureus / drug effects*
Substances
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Anti-Bacterial Agents
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Quinones
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Sesquiterpenes