Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography

J Med Chem. 2000 Nov 16;43(23):4359-62. doi: 10.1021/jm0009843.
No abstract available

MeSH terms

  • Animals
  • Brain / anatomy & histology
  • Brain / metabolism*
  • CHO Cells
  • Carbon Radioisotopes
  • Cell Line
  • Cricetinae
  • Drug Design
  • Humans
  • Isotope Labeling
  • Ligands
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / metabolism
  • Pyrazoles / pharmacokinetics
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / metabolism
  • Pyrimidines / pharmacokinetics
  • Rats
  • Receptor, Adenosine A2A
  • Receptors, Purinergic P1 / metabolism*
  • Recombinant Proteins / metabolism
  • Tissue Distribution
  • Tomography, Emission-Computed
  • Transfection

Substances

  • Carbon Radioisotopes
  • Ligands
  • Pyrazoles
  • Pyrimidines
  • Receptor, Adenosine A2A
  • Receptors, Purinergic P1
  • Recombinant Proteins
  • SCH 442416