Microscopic polyarteritis with renal and cerebral involvement

Pediatr Nephrol. 2000 Nov;15(1-2):134-5. doi: 10.1007/s004670000428.

Abstract

We report a 15-year-old girl who presented with renal failure requiring dialysis and a diagnosis of p-ANCA-associated vasculitis. She subsequently developed cerebral vasculitis during treatment with oral cyclophosphamide and prednisolone. Treatment with intravenous cyclophosphamide and plasma exchange produced a complete recovery.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / etiology*
  • Acute Kidney Injury / therapy
  • Adolescent
  • Antibodies, Antineutrophil Cytoplasmic / blood
  • Brain / pathology*
  • Cyclophosphamide / adverse effects
  • Cyclophosphamide / therapeutic use
  • Female
  • Glomerulonephritis / etiology*
  • Glomerulonephritis / therapy
  • Humans
  • Magnetic Resonance Imaging
  • Occipital Lobe / pathology
  • Peritoneal Dialysis
  • Plasma Exchange
  • Polyarteritis Nodosa / complications*
  • Polyarteritis Nodosa / diagnosis*
  • Polyarteritis Nodosa / therapy
  • Prednisolone / adverse effects
  • Prednisolone / therapeutic use
  • Vasculitis / diagnosis*
  • Vasculitis / etiology
  • Vasculitis, Central Nervous System / diagnosis*
  • Vasculitis, Central Nervous System / etiology

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Cyclophosphamide
  • Prednisolone