[Comparative study of hemodynamic effects of antidepressants (tetrindole and desipramine) during immobilization stress in hypertensive rats]

V A Korshunov; A N Murashev; M N Ivashev; S F Dugin; O S Medvedev

[Comparative study of hemodynamic effects of antidepressants (tetrindole and desipramine) during immobilization stress in hypertensive rats]

Eksp Klin Farmakol. 2000 Sep-Oct;63(5):18-20.

[Article in Russian]

Authors

V A Korshunov¹, A N Murashev, M N Ivashev, S F Dugin, O S Medvedev

Affiliation

¹ Pushchino Department, Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

PMID: 11109518

Abstract

Tetrindole (a tetracyclic antidepressant, reversible MAO inhibitor of the A type) and desipramine (a tricyclic antidepressant, nonselective inhibitor of the reverse catecholamine trapping) produce opposite hemodynamic effects in stroke-prone hypertensive rats (SHR-SP): tetrindole reduced, whereas desipramine increased, the heart rate and arterial pressure. Under the acute immobilization stress conditions in SHR-SP, tetrindole inhibited development of the post-stressor tachycardia, while desipramine did not change the heart rate and increased the arterial pressure.

Publication types

English Abstract

MeSH terms

Animals
Antidepressive Agents / adverse effects
Antidepressive Agents / pharmacology*
Blood Pressure / drug effects
Carbazoles / adverse effects
Carbazoles / pharmacology*
Desipramine / adverse effects
Desipramine / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / complications
Hypertension / physiopathology*
Immobilization
Male
Rats
Rats, Inbred SHR
Stress, Psychological / complications
Stress, Psychological / physiopathology*
Structure-Activity Relationship

Substances

Antidepressive Agents
Carbazoles
tetrindole
Desipramine