Retinoic acid enhances the rate of olfactory recovery after olfactory nerve transection

Brain Res Dev Brain Res. 2000 Nov 30;124(1-2):129-32. doi: 10.1016/s0165-3806(00)00108-5.

Abstract

In the olfactory system, retinoic acid (RA) plays an important role in development and may affect growth in the adult animal. To explore the potential effects of RA on recovery after injuries, adult mice were trained in a buried food paradigm and were given a single oral supplement of RA after olfactory nerve transection. Results demonstrate that RA accelerates the recovery of olfactory functions after injury.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Denervation*
  • Male
  • Mice
  • Mice, Inbred CBA
  • Nerve Regeneration / drug effects*
  • Olfaction Disorders / etiology*
  • Olfaction Disorders / physiopathology*
  • Olfactory Nerve / physiopathology*
  • Olfactory Pathways / physiopathology*
  • Smell / drug effects
  • Tretinoin / pharmacology*

Substances

  • Tretinoin