Abstract
DAP12, an ITAM-bearing transmembrane adaptor protein, associates non-covalently with receptors in natural killer (NK) and myeloid cells, and provides signaling function via the Syk and ZAP-70 tyrosine kinase activation pathways. Humans and mice lacking DAP12 (DAP12(-/-)) show normal development of hematopoietic cells. However, DAP12(-/-) humans develop presenile dementia and bone cysts, and DAP12(-/-) mice show impaired immune responses.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Alzheimer Disease / enzymology
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Alzheimer Disease / genetics
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Amino Acid Motifs
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Animals
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Bone Cysts / enzymology
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Bone Cysts / genetics
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Enzyme Precursors / physiology
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Hematopoiesis / physiology
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Humans
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Immunologic Deficiency Syndromes / genetics
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Immunologic Deficiency Syndromes / metabolism
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Intracellular Signaling Peptides and Proteins
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Killer Cells, Natural / metabolism*
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Killer Cells, Natural / physiology
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Membrane Proteins
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Mice
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Mice, Knockout
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Models, Animal
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Myeloid Cells / metabolism*
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Myeloid Cells / physiology
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Organ Specificity
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Protein-Tyrosine Kinases / physiology
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Receptors, Cell Surface / chemistry
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Receptors, Cell Surface / physiology
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Receptors, Immunologic / chemistry
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Receptors, Immunologic / deficiency
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Receptors, Immunologic / genetics
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Receptors, Immunologic / physiology*
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Signal Transduction
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Species Specificity
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Syk Kinase
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ZAP-70 Protein-Tyrosine Kinase
Substances
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Adaptor Proteins, Signal Transducing
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Enzyme Precursors
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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Receptors, Cell Surface
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Receptors, Immunologic
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TYROBP protein, human
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Protein-Tyrosine Kinases
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SYK protein, human
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Syk Kinase
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Syk protein, mouse
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ZAP-70 Protein-Tyrosine Kinase
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ZAP70 protein, human
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Zap70 protein, mouse