Abstract
We measured thymidine phosphorylase activity in colorectal cancer tissue and conducted immunostaining to investigate enzyme expression in the tumor tissue. The results showed a correlation between staining ratio of thymidine phosphorylase and cancer progression as well as a correlation between enzyme activity and staining ratios of cancer cells and stromal cells. Since enzyme activity levels can be judged by staining ratios, this method may be useful for assessing cancer malignancy.
MeSH terms
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Adenocarcinoma / enzymology*
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Adenocarcinoma / mortality
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Adenocarcinoma / pathology
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Adenocarcinoma / secondary
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Adenoma / enzymology*
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Adenoma / mortality
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Adenoma / pathology
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Aged
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Antimetabolites, Antineoplastic / metabolism
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Biomarkers, Tumor / analysis*
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Biotransformation
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Capecitabine
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Colorectal Neoplasms / enzymology*
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Colorectal Neoplasms / mortality
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Colorectal Neoplasms / pathology
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Deoxycytidine / analogs & derivatives
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Deoxycytidine / metabolism
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Female
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Floxuridine / metabolism
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Fluorouracil / metabolism
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Humans
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Liver Neoplasms / enzymology
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Liver Neoplasms / secondary
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Lymphatic Metastasis
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Male
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Middle Aged
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Neoplasm Invasiveness
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Neoplasm Proteins / analysis*
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Neoplasm Proteins / metabolism
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Neoplastic Stem Cells / pathology
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Prodrugs / metabolism
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Prognosis
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Stromal Cells / pathology
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Thymidine Phosphorylase / analysis*
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Thymidine Phosphorylase / metabolism
Substances
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Antimetabolites, Antineoplastic
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Biomarkers, Tumor
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Neoplasm Proteins
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Prodrugs
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Floxuridine
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Deoxycytidine
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Capecitabine
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Thymidine Phosphorylase
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Fluorouracil
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doxifluridine