Abstract
We describe 2 patients who were initially positive for antibodies to hepatitis B surface antigen and who experienced a strong and sudden increase of hepatitis B virus (HBV) replication during highly active antiretroviral therapy (HAART). We found that reactivation of HBV replication during HAART can occur independently of lamivudine resistance or withdrawal of lamivudine, and in spite of increasing CD4(+) cell counts.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / drug therapy
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AIDS-Related Opportunistic Infections / immunology
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AIDS-Related Opportunistic Infections / virology*
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Adult
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Aged
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Amino Acid Sequence
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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Antiretroviral Therapy, Highly Active / adverse effects
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DNA, Viral / blood
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Hepatitis B / drug therapy
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Hepatitis B / immunology
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Hepatitis B / virology*
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Hepatitis B virus / genetics
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Hepatitis B virus / growth & development*
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Humans
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Lamivudine / adverse effects*
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Lamivudine / therapeutic use
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Male
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Molecular Sequence Data
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Reverse Transcriptase Inhibitors / adverse effects*
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Reverse Transcriptase Inhibitors / therapeutic use
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Virus Activation*
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Virus Replication
Substances
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Anti-HIV Agents
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DNA, Viral
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Reverse Transcriptase Inhibitors
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Lamivudine