The SH3-fold family: experimental evidence and prediction of variations in the folding pathways

J Mol Biol. 2000 Dec 15;304(5):967-82. doi: 10.1006/jmbi.2000.4234.

Abstract

To investigate the relationships between protein topology, amino acid sequence and folding mechanisms, the folding transition state of the Sso7d protein has been characterised both experimentally and theoretically. Although Sso7d protein has a similar topology to that of the SH3 domains, the structure of its transition state is different from that of alpha-spectrin and src SH3 domains previously studied. The folding algorithm, Fold-X, including an energy function with specific sequence features, accounts for these differences and reproduces with a good agreement the set of experimental phi(double dagger-U) values obtained for the three proteins. Our analysis shows that taking into account sequence features underlying protein topology is critical for an accurate prediction of the folding process.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Amino Acid Sequence
  • Archaeal Proteins*
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / genetics
  • Entropy
  • Hydrogen Bonding
  • Kinetics
  • Models, Molecular
  • Molecular Sequence Data
  • Mutation / genetics
  • Protein Denaturation
  • Protein Engineering
  • Protein Folding*
  • Protein Structure, Secondary
  • Sequence Alignment
  • Software
  • Spectrin / chemistry*
  • Spectrin / genetics
  • Thermodynamics
  • src Homology Domains* / genetics

Substances

  • Archaeal Proteins
  • DNA-Binding Proteins
  • Sso7d protein, Sulfolobus
  • Spectrin