Abstract
Classical embryology has provided a clear view of the timing and hormonal cues that govern sexual differentiation. Molecular biology has added important details to this picture. The cloning of SRY, MIS, and INSL3 provide insight into the molecular signals that provide important cues at the cellular level. Continued understanding of these pathways may provide the necessary information to one day reverse defects of sexual differentiation.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Mullerian Hormone
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Estrogens / physiology
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Fertility / genetics
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Genitalia, Male / embryology
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Genitalia, Male / growth & development*
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Glycoproteins*
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Growth Inhibitors / genetics
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Growth Inhibitors / metabolism
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Hormones / physiology*
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Humans
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Insulin
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Male
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Proteins / genetics
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Proteins / metabolism
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Sex Differentiation / physiology*
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Testicular Hormones / genetics
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Testicular Hormones / metabolism
Substances
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Estrogens
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Glycoproteins
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Growth Inhibitors
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Hormones
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Insulin
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Leydig insulin-like protein
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Proteins
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Testicular Hormones
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Anti-Mullerian Hormone