Use of hydroxyapatite to fill cavities after excision of benign bone tumours. Clinical results

J Bone Joint Surg Br. 2000 Nov;82(8):1117-20. doi: 10.1302/0301-620x.82b8.11194.

Abstract

We treated 75 patients with benign bone tumours by curettage and filling the defect with calcium hydroxyapatite (HA). There were 28 women and 47 men with a mean age of 27.7 years (3 to 80). The mean follow-up was for 41.3 months. Postoperative radiological assessment revealed that the implanted HA was well incorporated into the surrounding host bone in all patients. Two patients suffered fractures in the postoperative period. Two patients complained of pain associated with HA in the soft tissues, but this diminished within six months. No patient had local pain at the final follow-up. Recurrence of the tumour was seen in three cases. Histopathological study of the implanted area showed removal of the HA by histiocytes and multinucleated giant cells, and the formation of much appositional bone. We conclude that HA is an excellent bone-graft substitute in surgery for benign bone tumours.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biocompatible Materials / adverse effects
  • Biocompatible Materials / therapeutic use*
  • Bone Neoplasms / diagnostic imaging
  • Bone Neoplasms / pathology
  • Bone Neoplasms / surgery*
  • Child
  • Child, Preschool
  • Curettage / adverse effects
  • Curettage / instrumentation
  • Curettage / methods
  • Durapatite / adverse effects
  • Durapatite / therapeutic use*
  • Female
  • Follow-Up Studies
  • Fractures, Spontaneous / diagnostic imaging
  • Fractures, Spontaneous / etiology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / etiology
  • Osseointegration
  • Osteotomy / adverse effects
  • Osteotomy / instrumentation
  • Osteotomy / methods
  • Pain, Postoperative / etiology
  • Splints
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Biocompatible Materials
  • Durapatite