Specific passive immunity reduces the excretion of glycoprotein E-negative bovine herpesvirus type 1 vaccine strain in calves

Vaccine. 2000 Dec 8;19(9-10):1013-7. doi: 10.1016/s0264-410x(00)00234-6.

Abstract

We investigated the excretion of either a glycoprotein E (gE)-negative bovine herpesvirus type 1 (BHV1) vaccine strain or a conventional modified-live vaccine strain in both naïve and passively immunised calves. The replication of gE-negative strain was considerably reduced in the maternally immunised calves, in comparison with the non-immune calves. On the other hand, the excretion of the gE-positive conventional vaccine strain was not reduced and even seemed to be prolonged in the presence of maternal antibodies. These results suggest that BHV1 gE may play a role in virus survival in the presence of antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cattle
  • Herpesvirus 1, Bovine / immunology*
  • Herpesvirus Vaccines / immunology*
  • Immunization, Passive
  • Viral Envelope Proteins / physiology*
  • Viral Proteins

Substances

  • Herpesvirus Vaccines
  • Viral Envelope Proteins
  • Viral Proteins
  • bovine herpesvirus type-1 glycoproteins