Abstract
For the diagnosis of Chagas' disease, the trans-sialidase inhibition assay was able to resolve the results for samples with borderline results, to detect as positive 60% of samples that were negative by conventional serology, and to discriminate idiopathic from chagasic megaviscera or cardiopathy. No cross-reaction with sera from patients with other diseases was observed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Protozoan / blood*
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Antibodies, Protozoan / immunology
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Antigens, Protozoan / immunology*
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Autoimmune Diseases / blood
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Autoimmune Diseases / immunology
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Brazil / epidemiology
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Chagas Disease / blood
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Chagas Disease / diagnosis*
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Chagas Disease / epidemiology
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Chagas Disease / immunology
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Cross Reactions
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Glycoproteins / antagonists & inhibitors*
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Glycoproteins / immunology
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Humans
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Leishmaniasis, Cutaneous / blood
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Leishmaniasis, Cutaneous / immunology
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Malaria / blood
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Malaria / immunology
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Neuraminidase / antagonists & inhibitors*
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Neuraminidase / immunology
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Neutralization Tests / methods
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Paraguay / epidemiology
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Sensitivity and Specificity
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Syphilis / blood
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Syphilis / immunology
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Trypanosoma cruzi / immunology
Substances
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Antibodies, Protozoan
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Antigens, Protozoan
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Glycoproteins
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trans-sialidase
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Neuraminidase